ASTM E2838 - 11(2016)

    Standard Test Method for Determination of Thiodiglycol on Wipes by Solvent Extraction Followed by Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

    Active Standard ASTM E2838 | Developed by Subcommittee: E54.03

    Book of Standards Volume: 15.08

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    Significance and Use

    5.1 This is a performance based method, and modifications are allowed to improve performance.

    5.1.1 Due to the rapid development of newer instrumentation and column chemistries changes to the analysis described in this standard are allowed as long as better or equivalent performance data result. Any modifications shall be documented and performance data generated. The user of the data generated by this Standard shall be made aware of these changes and given the performance data demonstrating better or equivalent performance.

    5.2 TDG is a Schedule 2 compound under the Chemical Weapons Convention (CWC).6 Schedule 2 chemicals include those that are precursors to chemical weapons, chemical weapons agents or have a number of other non-military commercial uses. Schedule 2 chemicals can also be found in applications unrelated to chemical weapons. These chemicals are used as ingredients to produce insecticides, herbicides, lubricants, and some pharmaceutical products. TDG is a mustard gas precursor and a degradant as well as an ingredient in water-based inks, ballpoint pen inks, dyes, and some pesticides.

    5.3 This method has been investigated for use on surface wipes. TDG is also a human metabolite resulting from sulfur mustard exposure but this method has not been investigated for such determinations.

    1. Scope

    1.1 This procedure details the determination of thiodiglycol (TDG), also known as 2,2’-thiobis-ethanol, on wipes with 3,3’-thiodipropanol (TDP) as the surrogate. This method is based upon solvent extraction of wipes by either sonication or a pressurized fluid extraction (PFE) technique as an alternative option. The extract is filtered, concentrated and analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). TDG is qualitatively and quantitatively determined.

    1.2 Units—The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

    1.3 The Method Detection Limit (MDL)2 and Reporting Range3 for TDG are listed in Table 1.

    1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

    (A) Chemical Abstract Service (CAS), A division of the American Chemical Society, 2540 Olentangy River Road, Columbus, OH, 43202, USA.

    2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.

    ASTM Standards

    D653 Terminology Relating to Soil, Rock, and Contained Fluids

    D1193 Specification for Reagent Water

    D3694 Practices for Preparation of Sample Containers and for Preservation of Organic Constituents

    D3740 Practice for Minimum Requirements for Agencies Engaged in Testing and/or Inspection of Soil and Rock as Used in Engineering Design and Construction

    E2554 Practice for Estimating and Monitoring the Uncertainty of Test Results of a Test Method Using Control Chart Techniques

    Other Documents

    EPA Publication SW-846 Test Methods for Evaluating Solid Waste, Physical/Chemical Methods Available from National Technical Information Service (NTIS), U.S. Department of Commerce, 5285 Port Royal Road, Springfield, VA, 22161 or at

    The Code of Federal Regulations, 40 CFR Part 136, Appendix B

    UNSPSC Code

    UNSPSC Code

    Referencing This Standard
    Link Here
    Link to Active (This link will always route to the current Active version of the standard.)

    DOI: 10.1520/E2838-11R16

    ASTM International is a member of CrossRef.

    Citation Format

    ASTM E2838-11(2016), Standard Test Method for Determination of Thiodiglycol on Wipes by Solvent Extraction Followed by Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS), ASTM International, West Conshohocken, PA, 2016,

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