ASTM E1811-96(2005)e1

    Withdrawn Standard: ASTM E1811-96(2005)e1 Standard Test Method for Oncogenicity Study in Rats and Mice (Withdrawn 2010)

    Developed by Subcommittee: E47.02

    WITHDRAWN, NO REPLACEMENT

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    Withdrawn Rationale:

    This test method covers a long-term study to determine the oncogenicity potential of a substance in mammalian species such as the rat and mouse. The objective is to observe the test animals for a major portion of their life span for neoplastic lesions during exposure to various doses of a test substance by oral administration.

    Formerly under the jurisdiction of Committee E47 on Biological Effects and Environmental Fate, this test method was withdrawn in February 2010, because other guidelines currently exist.

    1. Scope

    1.1 This test method covers a long-term study to determine the oncogenicity potential of a substance in mammalian species such as the rat and mouse. the objective is to observe the test animals for a major portion of their life span for neoplastic lesions during exposure to various doses of a test substance by oral administration.

    1.2 This test may also provide some information on long-term general toxicity.

    1.3 This test method assumes that the user is knowledgeable in mammalian toxicology and related pertinent areas, and it relies heavily on the judgment of the evaluator.

    1.4 The values stated in SI units are to be regarded as the standard. The values given in parentheses are for information only.

    1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. Specific hazards statements are given in Section 6.


    2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.

    ASTM Standards

    E609 Definitions of Terms Relating to Pesticides

    E943 Terminology Relating to Biological Effects and Environmental Fate

    Federal Standards

    Title40 CFR, Part 792, Good Laboratory Practice Standards, Toxic Substance Control Act


    DOI: 10.1520/E1811-96R05E01

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