ASTM E1373-01(2005)e1

    Standard Test Method for Conducting a Subchronic Inhalation Toxicity Study in Rats (Withdrawn 2009)

    Withdrawn Standard: ASTM E1373-01(2005)e1 | Developed by Subcommittee: E47.02

    WITHDRAWN, NO REPLACEMENT


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    Withdrawn Rationale:

    This test method determines the no observed-effect level (NOEL) and toxic effects associated with continuous or repeated inhalation exposure to a chemical, pesticide, or mixture for a period of 90 days. The test is not capable of determining those effects that have a long latency period for development (for example, carcinogenicity and life shortening).

    Formerly under the jurisdiction of Committee E47 on Biological Effects and Environmental Fate, this test method was withdrawn in November 2009. This standard is being withdrawn with no replacement because other more appropriate methods exist.

    1. Scope

    1.1 This test method determines the no observed-effect level (NOEL) and toxic effects associated with continuous or repeated inhalation exposure to a chemical, pesticide, or mixture for a period of 90 days. The test is not capable of determining those effects that have a long latency period for development (for example, carcinogenicity and life shortening).

    1.2 This test method which is applicable to a gas, vapor, aerosol, or particulate is conducted after initial information on toxicity is obtained by acute testing.

    1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.



    2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.

    ASTM Standards

    E609 Terminology Relating to Pesticides

    E943 Terminology Relating to Biological Effects and Environmental Fate

    Federal Standards

    Title40, Code of Federal Regulations (CFR), Toxic Substance Control Act, Part 792, Good Laboratory Practice Standards


    DOI: 10.1520/E1373-01R05E01

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