Withdrawn Rationale:
This test method has been designed to examine the subchronic oral toxicity of a test substance during a 90-day period of continuous oral exposure to rats (Rattus norvegicus) following initial acute toxicity tests.
Formerly under the jurisdiction of Committee E47 on Biological Effects and Environmental Fate, this test method was withdrawn in February 2010, because other guidelines currently exist.
1. Scope
1.1 This test method has been designed to examine the subchronic oral toxicity of a test substance during a 90-day period of continuous oral exposure to rats (Rattus norvegicus) following initial acute toxicity tests.
1.2 The values stated in SI units are to be regarded as the standard. The values given in parentheses are for information only.
1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
Keywords
blood chemistry; cumulative toxicity; feed efficiency; gavage; hematology; histopathology; LD50; necropsy; no observed effect dose (NOED); oral; pesticide; rat; subchronic; toxicity; urinalysis
DOI: 10.1520/E1372-95R03
ASTM International is a member of CrossRef.
Citing ASTM Standards
[Back to Top]
