1. Scope
1.1 This guide defines acute animal toxicity tests and sets forth the references for procedures to assess the acute toxicity of water-miscible metalworking fluids as manufactured.
1.2 Although water-miscible metalworking fluids are typically used at high dilution, dilution rates vary widely. Additionally, there is potential for exposure to the metalworking fluid as manufactured.
This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
2. Referenced Documents (purchase separately) 
The documents listed below are referenced within the subject standard but are not provided as part of the standard.
ASTM Standards
E758 Test Method for Mammalian Acute Percutaneous Toxicity
E981 Test Method for Estimating Sensory Irritancy of Airborne Chemicals
E993 Test Method for Evaluation of Delayed Contact Hypersensitivity
E1103 Test Method for Determining Subchronic Dermal Toxicity
CPSC Standards
16 CFR Part 1500.42
DOT Standards
49 CFR Part 173.343a3
EPA-TSCA Standards
40 CFR 870.2600
OSHA Standards
29 CFR 1910.1200 Appendix A, 4
Index Terms
acute toxicity testing; dermal; eye; inhalation; metalworking fluids; oral;
ICS Code
ICS Number Code 11.120.01 (Pharmaceutics in general)
DOI: 10.1520/E1302-00R07
ASTM International is a member of CrossRef.
Citing ASTM Standards
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