ASTM E1147-92(2005)

    Standard Test Method for Partition Coefficient (N-Octanol/Water) Estimation by Liquid Chromatography (Withdrawn 2013)

    Withdrawn Standard: ASTM E1147-92(2005) | Developed by Subcommittee: E47.04

    WITHDRAWN, NO REPLACEMENT


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    Withdrawn Rationale:

    This test method describes a procedure for the estimation of the log of the octanol/water partition coefficient (log Kow) of chemicals over the range from 0 to 8.

    Formerly under the jurisdiction of Committee E47 on Biological Effects and Environmental Fate, this test method was withdrawn in March 2013. This standard is being withdrawn without replacement due to its limited use by industry.

    1. Scope

    1.1 This test method describes a procedure for the estimation of the log of the octanol/water partition coefficient (log Kow) of chemicals over the range from 0 to 8.

    1.2 This test method uses an empirically derived equation to relate the octanol/water partition coefficient to an experimentally determined retention time on a liquid chromatographic column.

    1.3 This test method has been designed to estimate log Kow values for both non-ionizable and ionizable compounds. This is accomplished by buffering the liquid chromatographic solvent at a pH that will force the test compound into either the non-ionized or ionized form.

    1.4 This test method requires some knowledge of the detector response to the chemical being tested.

    1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish safety and health practices and determine the applicability of regulatory limitations prior to use.



    2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.

    ASTM Standards

    D1193 Specification for Reagent Water

    E200 Practice for Preparation, Standardization, and Storage of Standard and Reagent Solutions for Chemical Analysis

    E682 Practice for Liquid Chromatography Terms and Relationships

    E1022 Guide for Conducting Bioconcentration Tests with Fishes and Saltwater Bivalve Mollusks


    DOI: 10.1520/E1147-92R05

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