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This test method describes a procedure for the assessment and evaluation of the toxic characteristics of a test substance that is applied daily to the skin of experimental animals for 90 days.
Formerly under the jurisdiction of Committee E47 on Biological Effects and Environmental Fate, this test method was withdrawn in February 2010, because other guidelines currently exist.
1.1 This test method describes a procedure for the assessment and evaluation of the toxic characteristics of a test substance that is applied daily to the skin of experimental animals for 90 days.
1.2 This test method is not capable of determining effects that have a long latency period (for example, carcinogenicity) or are life shortening.
1.3 This test method is intended primarily to be used with rats, guinea pigs, or rabbits. Other species may be used with appropriate modifications.
1.4 This standard does not purport to address the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
E609 Terminology Relating to Pesticides
E943 Terminology Relating to Biological Effects and Environmental Fate
Federal StandardsTitle40, Code of Federal Regulations (CFR), Subchapter R, Toxic Substance Control Act, Part 792, Good Laboratory Practice Standards