ASTM D4626 - 95(2010)

    Standard Practice for Calculation of Gas Chromatographic Response Factors

    Active Standard ASTM D4626 | Developed by Subcommittee: D02.04.0L

    Book of Standards Volume: 05.02


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    Significance and Use

    ASTM standard gas chromatographic methods for the analysis of petroleum products require calibration of the gas chromatographic system by preparation and analysis of specified reference mixtures. Frequently, minimal information is given in these methods on the practice of calculating calibration or response factors. Test Methods D2268, D2427, D2804, D2998, D3329, D3362, D3465, D3545, and D3695 are examples. The present practice helps to fill this void by providing a detailed reference procedure for calculating response factors, as exemplified by analysis of a standard blend of C6 to C11 n-paraffins using n-C12 as the diluent.

    In practice, response factors are used to correct peak areas to a common base prior to final calculation of the sample composition. The response factors calculated in this practice are multipliers and prior to final calculation of the results the area obtained for each compound in the sample should be multiplied by the response factor determined for that compound.

    It has been determined that values for response factors will vary with individual installations. This may be caused by variations in instrument design, columns, and experimental techniques. It is necessary that chromatographs be individually calibrated to obtain the most accurate data.

    1. Scope

    1.1 This practice covers a procedure for calculating gas chromatographic response factors. It is applicable to chromatographic data obtained from a gaseous mixture or from any mixture of compounds that is normally liquid at room temperature and pressure or solids, or both, that will form a solution with liquids. It is not intended to be applied to those compounds that react in the chromatograph or are not quantitatively eluted. Normal C6 through C11 paraffins have been chosen as model compounds for demonstration purposes.

    1.2 The values stated in SI units are to be regarded as the standard. The values stated in inch-pound units are for information only.

    1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.


    2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.

    ASTM Standards

    D2268 Test Method for Analysis of High-Purity n-Heptane and Isooctane by Capillary Gas Chromatography

    D2427 Test Method for Determination of C2 through C5 Hydrocarbons in Gasolines by Gas Chromatography

    D2804 Test Method for Purity of Methyl Ethyl Ketone By Gas Chromatography

    D2998 Test Method for Polyhydric Alcohols in Alkyd Resins

    D3329 Test Method for Purity of Methyl Isobutyl Ketone by Gas Chromatography

    D3362 Test Method for Purity of Acrylate Esters by Gas Chromatography

    D3465 Test Method for Purity of Monomeric Plasticizers by Gas Chromatography

    D3545 Test Method for Alcohol Content and Purity of Acetate Esters by Gas Chromatography

    D3695 Test Method for Volatile Alcohols in Water by Direct Aqueous-Injection Gas Chromatography

    D4307 Practice for Preparation of Liquid Blends for Use as Analytical Standards

    E260 Practice for Packed Column Gas Chromatography


    ICS Code

    ICS Number Code 71.040.50 (Physicochemical methods of analysis)

    UNSPSC Code

    UNSPSC Code 15121501(Engine oil)


    DOI: 10.1520/D4626-95R10

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