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    Titanium, Niobium, Zirconium, and Tantalum for Medical and Surgical Applications

    Zardiackas LD, Freese HL, Kraay MJ
    Published: 2006

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    Reactive metals and their alloys are used in a variety of biomedical applications from pace makers to hips implants. This new ASTM publication provides the latest developments on these alloys, their processing techniques for medical applications, characterization of fundamental materials properties critical to their use for biomedical applications, and evaluation of biological and clinical performance.

    Eighteen peer-reviewed papers cover:

    Alloy Processing—includes information on the formulation and processing of five important, new implantable metallic biomaterials:
    • Ti-12Mo-6Zr-2Fe alloy ("TMZF")
    • Zr-2.5Nb alloy ("Oxidized Zirconium", "Oxinium")
    • Tantalum foam ("Trabecular Metal")
    • Ti-35Nb-7Zr-5Ta alloy ("TiOsteum")
    • Ti-15Mo alloy

    Alloy Properties—focuses on the bulk and surface properties, especially stress corrosion cracking and fatigue, of a number of different titanium alloys, which may be used for implants. Additional information is provided on the fracture mechanisms of several of these alloys.

    Biological and Clinical Evaluation—deals with the biological and clinical evaluation of titanium, niobium, zirconium and tantalum used in the medical and surgical setting, including a new method of grit-blasting for implant surfaces, clinical evaluation of 14 retrieved modular body (SROM) total hip stems removed at the time of revision surgery, and a practical methodology to generate titanium and stainless steel wear debris particles for use in further study of the process of osteolysis and its treatment.

    Table of Contents

    Mechanical and Physical Properties of Titanium-12Molybdenum-6Zirconium-2Iron Beta Titanium Alloy

    Creation of Oxidized Zirconium Ortliopaedic Implants

    Metallurgical Attachment of a Porous Tantalum Foam to a Titanium Substrate for Orthopedic Applications

    Influence of Oxygen Content on the Mechanical Properties of Titanium-35Niobium-7Zirconium-5Tantalum Beta Titanium Alloy

    Effect of Aging Treatments on the Tensile Properties of Ti-35Nb-7Zr-5Ta-(0.06-0.7)O Alloys

    Beta Titanium Alloy Processed for High Strength Orthopedic Applications

    The Application of Ti-15Mo Beta Titanium Alloy in High Strength Structural Orthopaedic Applications

    Mechanical Properties of Cast Ti-Fe-0-N Alloys

    Effect of Surface Reaction Layer on Three-Point Flexure Bond Strength of Resin Composite to Cast Ti and Ti-6AI-7Nb

    Corrosion Resistance, Mechanical Properties, Fatigue Properties, and Tissue Response of Ti-15Zr-4Nb-4Ta Alloy

    Super Elastic Functional β Titanium Alloy with Low Young's Modulus for Biomedical Applications

    Comparative Evaluations of Surface Characteristics of cp Titanium, Ti-6AI-4V and Ti-15Mo-2.8Nb-0.2Si (Timetal® 21SRx)

    Comparison of Stress Corrosion Cracking and Corrosion Fatigue (Anodized and Non-Anodized Grade 4 CP Ti)

    Comparison of the Corrosion Fatigue Characteristics of CP Ti-Grade 4, Ti-6AI-4V ELI, Ti-6AI-7Nb, and Ti-15Mo

    Comparison of Stress Corrosion Cracking Characteristics of CP Ti, Ti-6AI-7Nb, Ti-6AI-4V, and Ti-15IVIo

    Corrosion of Modular Titanium Alloy Stems in Cementless Hip Replacement

    Influence of Exposure Conditions on Bacterial Adhesion to Zirconium Alloys

    A Methodology to Fabricate Titanium and Stainless Steel Wear Debris for Experimental Use: A Comparison of Size, Shape, and Chemistry

    Zirconium and Niobium Affect Human Osteoblasts, Fibroblasts, and Lymphocytes in a Similar Manner to More Traditional Implant Alloy Metals


    Committee: F04

    DOI: 10.1520/STP1471-EB

    ISBN-EB: 978-0-8031-5511-4

    ISBN-13: 978-0-8031-3497-3

    ASTM International is a member of CrossRef.