Particulate Debris from Medical Implants: Mechanisms of Formation and Biological Consequences

    St. John KR
    Published: 1992

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    One of the causes or results (or both) of medical implant failure is the release of particulate material debris from the device because of wear, physical deterioration, or chemical attack by the harsh physiological environment. STP 1144 examines tissue response to particles of implant material in order to identify factors, such as materials selection, surgical protocol, implant design, or postoperative prophylactic drug treatment, that might limit debris generation or moderate the tissue response.

    19 peer-reviewed papers written by principal researchers in the field are divided into two sections: clinical experience with the generation of material debris from implants; and in vitro and in vivo models for the clinical situation and methods for generating and characterizing wear debris particles that may be used in laboratory models. For medical implant designers/orthopaedics, orthopaedic surgeons, medial libraries, and biomaterials researchers.

    Table of Contents

    St. John K.

    Debris-Mediated Osteolysis—A Cascade Phenomenon Involving Motion, Wear, Particulates, Macrophage Induction, and Bone Lysis
    Campbell P., Clarke I., Kossovsky N.

    Clinical and Experimental Studies in the Biology of Aseptic Loosening of Joint Arthroplasties and the Role of Polymer Particles
    Fornasier V., Goodman S.

    Histopathological Effects of Ultrahigh-Molecular-Weight Polyethylene and Metal Wear Debris in Porous and Cemented Surface Replacements
    Amstutz H., Campbell P., Kossovsky N., Nasser S.

    Particulate-Associated Endosteal Osteolysis in Titanium-Base Alloy Cementless Total Hip Replacement
    Galante J., Gavrilovic J., Jacobs J., Schajowicz F., Urban R.

    Endosteal Osteolysis Around Well-Fixed Porous-Coated Cementless Femoral Components
    Callaghan J., Galante J., Harris W., Jasty M., Maloney W.

    Photon Correlation Spectroscopy Analysis of the Submicrometre Particulate Fraction in Human Synovial Tissues Recovered at Arthroplasty or Revision
    Amstutz H., Campbell P., Finerman G., Gelman A., Kossovsky N., Liao K., Nasser S., Thomas B.

    Failure Mechanism of a Metal-Backed Patella: An Implant Retrieval Study
    Bauer T., Merritt K., Schickendantz M., Stulberg B.

    Use of Profile Imaging to Assess Patellofemoral Congruity: Implications for Assessing Patellofemoral Wear in Total Knee Arthroplasty
    de Swart R., Easley K., Reger S., Stulberg B.

    Histomorphological Reaction Patterns of the Bone to Diverse Particulate Implant Materials in Man and Experimental Animals
    Boss J., Mendes D., Shajrawi I., Soudry M.

    Prostaglandin E2 Synthesis by the Tissue Surrounding Ultrahigh Molecular Weight Polyethylene in Different Physical Forms
    Chin R., Chiou S., Goodman S., Lee J.

    A Comparison of the Biocompatibility of Polymethyl Methacrylate Debris With and Without Titanium Debris: A Comparison of Two In Vivo Models
    Baker D., Cuckler J., Ducheyne P., Imonitie V., Mitchell J., Schumacher H.

    Biocompatibility of Polymethyl Methacrylate With and Without Barium Sulfate in the Rat Subcutaneous Air Pouch Model
    Baker D., Cuckler J., Ducheyne P., Imonitie V., Lazarus M., Mitchell J., Schumacher H.

    In Vitro Activation of Monocyte Macrophages and Fibroblasts by Metal Particles
    Bennett N., Goldring S., Jasty M., Wang J.

    In Vitro Cellular Activation by Fabricated and Clinically Retrieved Bone Cement Wear Particles
    Emmanual J., Hedley A.

    Human Plasma Adsorption to Particulate Arthroplastic Component Materials In Vitro
    Campbell P., Feng D., Kossovsky N., Millett D.

    Correlation Between the Metal Ion Concentration and the Fretting Wear Volume of Orthopaedic Implant Metals
    Daigle K., Davidson J., Kovacs P.

    Preparation, Characterization, and Animal Testing for Biocompatibility of Metal Particles of Iron-, Cobalt-, and Titanium-Based Implant Alloys
    Buchhorn G., Schmidt M., Schoen R., Semlitsch M., Steinemann S., Willert H.

    Polymer Particles In Vivo: Distribution in the Knee, Migration to Lymph Nodes, and Associated Cellular Response Following Anterior Cruciate Ligament Replacement
    Lemons J., Macon N., Niemann K.

    Use of an Anticollagenase Antibody to Study Synovial Cell Interactions with Particulate Material
    Evans C., Fu F., Georgescu H., Greis P.

    Author Index

    Subject Index

    Committee: F04

    DOI: 10.1520/STP1144-EB

    ISBN-EB: 978-0-8031-5202-1

    ISBN-13: 978-0-8031-1441-8

    ASTM International is a member of CrossRef.