STP1466

    The Role of TGA-DTA in the Initial Evaluation of the Solid State Forms for Pharmaceutical New Chemical Entities, Part 1: Evaluation of Pure Forms

    Published: Jan 2007


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    Abstract

    TGA-DTA plays a central role in the strategy outlined for early evaluation of the solid state forms available to pharmaceutical new chemical entities. At this early stage of development, compound and time are typically at a premium, so a successful strategy requires making the best possible use of the materials and time available. In addition, because of time and compound limitations, the goal of a solid state investigation is focused upon early stage objectives rather than development of a complete understanding of all available solid state forms. The TGA-DTA is well suited to addressing these needs.

    Keywords:

    TGA, DTA, hydrate, thermal analysis, hygroscopicity, pharmaceutical


    Author Information:

    Redman-Furey, Nancy L.
    Principal Scientist, P&G Pharmaceuticals, Inc., Norwich, New York

    Dicks, Michael L.
    Principal Researcher, P&G Pharmaceuticals, Inc., Norwich, New York

    Godlweski, Jane
    Principal Researcher, P&G Pharmaceuticals, Inc., Norwich, New York

    Vaughn, Dana C.
    Senior Researcher, P&G Pharmaceuticals, Inc., Norwich, New York

    Collins, Wendy J.
    Senior Researcher, P&G Pharmaceuticals, Inc., Norwich, New York


    Paper ID: STP45222S

    Committee/Subcommittee: E37.01

    DOI: 10.1520/STP45222S


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