STP732

    Characterization of the Inflammatory Response in Experimental Silicosis

    Published: Jan 1981


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    Abstract

    Six months after intratracheal instillation of silica, histologic, ultrastructural, and cytologic studies were performed to characterize the inflammatory response in the lungs of guinea pigs. Granulomatous and diffuse interstitial infiltration occurred predominantly in the peribronchial regions. Ultrastructural evaluation confirmed the presence of a mixed cellular infiltrate and fibrosis in the alveolar interstitium and Type II lining cell hyperplasia. Recovery of bronchoalveolar cells by whole lung lavage and the proportion of neutrophils and multinucleated giant cells in this population were significantly higher in experimental animals (p < 0.05) than in controls (intratracheal saline). Lung macrophages from experimental animals exhibited impaired adherence and motility in vitro. The mechanisms by which inflammatory cells might be recruited into the lungs of these animals and the importance of altered macrophage function are discussed.

    Keywords:

    quartz, silicosis, granulomas, macrophages, neutrophils, giant cells, fibrosis, inflammation


    Author Information:

    Dauber, JH
    Assistant professor of medicine, assistant professor of medicine, and associate professor of medicine and pathology, University of Pennsylvania, Philadelphia, Pa.

    Rossman, MD
    Assistant professor of medicine, assistant professor of medicine, and associate professor of medicine and pathology, University of Pennsylvania, Philadelphia, Pa.

    Daniele, RP
    Assistant professor of medicine, assistant professor of medicine, and associate professor of medicine and pathology, University of Pennsylvania, Philadelphia, Pa.


    Paper ID: STP38671S

    Committee/Subcommittee: E34.16

    DOI: 10.1520/STP38671S


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