SYMPOSIA PAPER Published: 01 January 1986
STP33288S

The Importance of Vascular Graft Surface Composition as Demonstrated by a New Gas Discharge Treatment for Small Diameter Grafts

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Biomaterial surface chemistry can have an important influence on biologic responses. Vascular graft chemistries may be modified in a number of ways. In this paper we report on a surface treatment using a gas discharge that deposits a thin coating onto the graft surface, significantly changing its surface chemistry, but without measurable change in porosity, compliance, or surface topography. Treatments with tetrafluoroethylene (TFE) gas yield dramatic improvements in both thrombo and emboli resistance of the graft, based on in vitro and ex vivo tests.

Author Information

Hoffman, AS
University of Washington, Center for Bioengineering (FL-20), Seattle, WA
Ratner, BD
University of Washington, Center for Bioengineering (FL-20), Seattle, WA
Garfinkle, AM
University of Washington, Center for Bioengineering (FL-20), Seattle, WA
Reynolds, LO
University of Washington, Center for Bioengineering (FL-20), Seattle, WA
Horbett, TA
University of Washington, Center for Bioengineering (FL-20), Seattle, WA
Hanson, SR
Scripps Clinic and Research Foundation, La Jolla, CA
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Developed by Committee: F04
Pages: 137–155
DOI: 10.1520/STP33288S
ISBN-EB: 978-0-8031-4966-3
ISBN-13: 978-0-8031-0462-4