This paper discusses some of the microstructural features which influence the creep properties of directionally solidified and single-crystal nickel-base superalloys. Gamma prime precipitate size and morphology, γ-γ' lattice mismatch, phase instability, alloy composition, and processing variations are among the factors considered. Recent experimental results are reviewed and related to the operative deformation mechanisms and to the corresponding mechanical properties. Special emphasis is placed on the creep behavior of single-crystal superalloys at high temperatures, where directional γ' coarsening is prominent, and at lower temperatures, where γ' coarsening rates are significantly reduced. It can be seen that very subtle changes in microstructural features can have profound effects on the subsequent properties of these materials.