STP921: Validation of collaborative testing guidelines

    Williams, LR
    Research biologist, Quality Assurance Division, Las Vegas, NV

    Meckley, DR
    Health scientist and task manager, ICAIR Division, Life Systems Incorporated, Cleveland, OH

    Schiefer, GE
    Health scientist and task manager, ICAIR Division, Life Systems Incorporated, Cleveland, OH

    Pages: 14    Published: Jan 1986


    Abstract

    This paper is an evaluation of the effectiveness of collaborative testing guidelines applied to two multi-laboratory method validation studies conducted for the U.S. Environmental Protection Agency (EPA). The guidelines were developed for EPA's Office of Toxic Substances and modeled after those of the Association of Official Analytical Chemists and The American Society for Testing and Materials. They were applied, to a greater or lesser extent, in the conduct of validation studies of the EPA's interim Ames test mutagenicity assay and Daphnia magna life-cycle toxicity assay. At the conclusion of the testing phase of the studies, each participant was requested to provide information related to key guideline elements. In addition, the organizers of each study indicated the degree to which they followed or did not follow the guidelines in administering their studies. Both participants and organizers were urged to provide recommendations for improving the way in which such studies are conducted in the future. The results are the basis for validation and appropriate revision of the collaborative testing guidelines. Results are presented and the implications of those results for future collaborative studies are discussed.

    Keywords:

    aquatic toxicology, collaborative study, collaborative testing, interlaboratory testing, test methods, biological methods, method validation, testing guidelines validation studies


    Paper ID: STP29036S

    Committee/Subcommittee: E47.10

    DOI: 10.1520/STP29036S


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