STP921

    Influence of Age on Patterns of Uptake and Excretion of Polycyclic Aromatic Hydrocarbons in the Rainbow Trout Embryo

    Published: Jan 1986


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    Abstract

    An investigation of the uptake, metabolism, and excretion of benzo(a)pyrene (B(a)P) and its metabolites in developing rainbow trout embryos and larvae, as well as the effects of mixed function oxygenase (MFO) inducers on these processes, has been conducted. The time of exposure during development has a significant effect on the rate of uptake and excretion, and MFO inducers can significantly influence the rate of excretion of the metabolites. In addition, the appearance of measurable B(a)P monooxygenase activity is related to the embryo's developmental stage, and embryonic trout metabolize B(a)P to compounds similar to those produced by adult fish and mammals.

    Keywords:

    aquatic toxicology, fish embryos, metabolism, benzo(a)pyrene


    Author Information:

    Stahl, RG
    Postdoctoral fellow, Department of Pathology, School of Medicine, and research associate professor, School of Fisheries, The University of Washington, Seattle, WA

    Central Research and Development Department, E. I. du Pont de Nemours & Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE

    Kocan, RM
    Postdoctoral fellow, Department of Pathology, School of Medicine, and research associate professor, School of Fisheries, The University of Washington, Seattle, WA


    Paper ID: STP29033S

    Committee/Subcommittee: E47.10

    DOI: 10.1520/STP29033S


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