STP921

    Bioconcentration, Detoxification, and Excretion of Mutagenic River Pollutants in Fish Bile

    Published: Jan 1986


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    Abstract

    The continuous presence of unknown Salmonella mutagens in XAD-concentrates of Rhine river water has been shown previously. Using nitro-reductase deficient bacterial strains and silica fractionation, it was strongly indicated that the responsible compounds may consist of nitro substituted aromatics (with additional polar groups or heterocyclic structures) and aromatic amines. It was further shown that the same type of mutagens could be detected (104-fold increase) in the bile of rainbow trout exposed to Rhine river water. Considerating the accumulated mutagenic activity in natural occurring fish, this observation argues in favor of a true bioconcentration process of water-borne mutagens in fish bile. The clearance of mutagenic activity of bile after transferring the fish to clean water again is indicative for the importance of biliary excretion of xenobiotics and their metabolites.

    Keywords:

    water pollution, mutagenicity, Salmonella, (Ames) mutagenicity test, identification, bioconcentration, biliary excretion, aquatic toxicology


    Author Information:

    van Kreijl, CF
    Senior scientist, Laboratory of Mutagenesis and Carcinogenesis, National Institute of Public Health and Environmental Hygiene, Bilthoven,

    de Zwart, D
    Research ecotoxicologist and section head, Laboratory of Ecology, Water, and Drinking Water, National Institute of Public Health and Environmental Hygiene, Bilthoven,

    Slooff, W
    Research ecotoxicologist and section head, Laboratory of Ecology, Water, and Drinking Water, National Institute of Public Health and Environmental Hygiene, Bilthoven,


    Paper ID: STP29031S

    Committee/Subcommittee: E47.10

    DOI: 10.1520/STP29031S


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