Published: Jan 1988
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The Analysis and Evaluation and the Industrial Technology Divisions in the Office of Water Regulations and Standards and the Environmental Protection Agency (EPA) Gulf Breeze Laboratory worked together to develop a protocol for a drilling fluid toxicity test to support the New Source Performance Standards/Best Available Technology Economically Achievable (NSPS/BAT) Effluent Guideline for the Offshore Segment of the Oil and Gas Extraction Industry. To evaluate the laboratory performance of this toxicity test, the Agency obtained data from ten laboratories. Each laboratory applied the toxicity test protocol to an EPA-provided sample of the same well-mixed, pretested batch of drilling fluid. The results of the toxicity test for each laboratory were compared with the results of a concurrent test by the EPA. The statistical procedures for comparison and evaluation of inter- and intralaboratory differences are presented. The basic procedure for the evaluation of laboratory performance and variability uses maximum likelihood estimation of the standard probit model with concomitant variables.
toxicity testing, dose-response analysis, probit analysis, quantal bioassay, laboratory evaluation, mysids, drilling fluid, nonlinear estimation, maximum likelihood estimation, Burrit analysis, covariate analysis, concomitant variables
Statistician, U.S. Environmental Protection Agency, Office of Water Regulations and Standards, Washington, DC
Statistician, SRI International, Menlo Park, CA