Professor of Physiology, University of Dayton, Dayton, OH
Research ceramist, University of Dayton Research Institute, University of Dayton, Dayton, OH
Research biologist, AAMRL, Wright-Patterson Air Force Base, OH
Laboratory manager, Research and Development, C. R. Bard Inc., Billerica, MA
Pages: 10 Published: Jan 1987
A porous aluminum-calcium-phosphorus oxide (ALCAP) ceramic has been developed for potential use in correcting bone defects. The material is at least partly resorbed and appears to have acceptable biocompatibility and toxicity characteristics for its intended applications. ALCAP ceramics are fabricated by calcining mixtures of aluminum, calcium, and phosphorus oxide powders and sintering the compressed blocks from calcined particles of the desired size. By varying the dimensions of the die, particle size, sintering time, and temperature, ALCAP ceramics have been fabricated that may be useful for repairing a wide variety of bone defects. The fate of ALCAP ceramics in both in vitro and in vivo environments has been studied by means of chemical analysis of tissues, chemical and enzyme analysis of implants, radiography, radioactive isotope uptake, scanning electron microscopy, energy-dispersive X-ray analysis, and histology. ALCAP ceramics were implanted in experimentally induced defects in long bones of rats and mandibles of rabbits. Results of these studies suggest that the ALCAP ceramics resorb and allow ingrowth of new bone.
porous implants, bone repair, aluminum-calcium-phosphorus oxide (ALCAP) ceramics, mutagenicity, spinal fusion, resorption, oral surgery, and maxillofacial surgery
Paper ID: STP25249S