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A Screening Test for Water Dispersible Granules Produced by Spray Drying Pages: 20 Published: Jan 1993
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View License Agreement The ability of a droplet of a liquid to spread on and disperse a thin film cast from spray dryer feedstock is an indication of the ability of WDGs prepared from that feedstock to be wet by and disintegrate in the same fluid. The relative wettabilities and disintegrabilities of a series of formulations or variations of a single formulation can be compared prior to spray dryer trials. In this manner, the effect of wetting agents, dispersants, binders, and particle size distributions on wettability and disintegrability of WDGs can be quickly evaluated using criteria closely related to actual manufacturing conditions. This will mitigate the need to resort to costly and time consuming, large spray dryer trials during the initial development of a formulation or screening trials for formulation development. Additionally, initial screening would become less dependent on the use of small laboratory dryers which often bear little or no relationship to large commercial spray dryers. Many of the factors responsible for loss of disintegrability and dispersional stability during storage can also be evaluated so specific solutions for storage related problems can be identified. | ||
