A transmission electron microscopy (TEM) investigation has been conducted on V-Ti, V-Ti-Cr, and V-Ti-Si alloys after neutron-irradiation at 420 and 600°C to fluences up to 114 dpa in the Fast Flux Test Facility (FFTF). Two types of irradiation-induced precipitates were identified, i.e., Ti²O and Ti⁵Si³, in addition to blocky Ti(O,N,C) that formed by thermal processes during ingot fabrication. Characteristics of the irradiation-induced precipitation were correlated with the swelling and mechanical properties of the irradiated alloys. In specimens where Ti⁵Si³ precipitation was significant, swelling was negligible. In specimens where Ti²O and Ti⁵Si³ precipitation was significant, ductility was relatively low.