Various oxide-dispersion-strengthened copper alloys have been irradiated to 150 dpa at 415°C in the Fast Flux Test Facility (FFTF). The Al²O³-strengthened GlidCop™ alloys, followed closely by a HfO²-strengthened alloy, displayed the best swelling resistance, electrical conductivity, and tensile properties. The conductivity of the HfO²-strengthened alloy reached a plateau at the higher levels of irradiation, instead of exhibiting the steady decrease in conductivity observed in the other alloys. A high initial oxygen content resulted in significantly higher swelling for a series of castable oxide-dispersion-strengthened alloys, while a Cr²O³-strengthened alloy showed poor resistance to radiation.