STP1124: Experimental Design for Pharmacokinetic Data Analysis Using Compartmental Pharmacokinetic Models

    Schultz, IR
    Graduate, Pharmacology/Toxicology and College of Pharmacy, Washington State University, Pullman, WA

    Hayton, WL
    Graduate, Pharmacology/Toxicology and College of Pharmacy, Washington State University, Pullman, WA

    Pages: 10    Published: Jan 1991


    Abstract

    Characterization of the pharmacokinetics of a chemical in fish is useful for estimation of the bioconcentration factor and half-life. Compartmental models that assume the fish to behave as one or more well-stirred compartments are the most common type of pharmacokinetic model used. A variety of experimental designs can be used with compartmental models where the fish is typically exposed via the water or through oral ingestion. Water exposures may be a continuous flow through design or static and the whole body concentration of chemical is determined. With increasing fish size, blood concentration may be added to the data set providing important information when multicompartmental models are used. As fish size increases, aortic cannulation and serial removal of blood becomes feasible, allowing the development of more complex compartmental models.

    Keywords:

    pharmacokinetics, fish, compartmental models, experimental design, uptake, elimination, bioconcentration


    Paper ID: STP23569S

    Committee/Subcommittee: E47.04

    DOI: 10.1520/STP23569S


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