SEDL / STP / STP1024-EB / STP22829S

Exercise and Regional Dosimetry: An Overview

Miller, FJ
Director, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle ParkNC,

McDonnell, WF
Director, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle ParkNC,

Gerrity, TR
Director, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle ParkNC,

Pages: 9    Published: Jan 1989

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Abstract

Regional respiratory tract dosimetry is an important consideration when examining susceptibility to inhaled gases and particles. In this overview, an orientation is provided on the major anatomical ventilatory and physiologic factors that affect regional respiratory tract dosimetry. The influence of these factors and the physical laws governing deposition exhibit complex relationships for the extrathoracic, tracheobronchial, and pulmonary regions of the respiratory tract. Specific examples of regional dosimetry of insoluble and hygroscopic particles and an oxidant gas are presented to help identify critical issues and research areas related to susceptibility to inhaled pollutants.