STP1096

    Peroxisome Proliferation as an Epigenetic Mechanism of Carcinogenesis: Relevance to Aquatic Toxicology

    Published: Jan 1990


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    Abstract

    This paper addresses the issue of epigenetic carcinogenesis in fish models with particular emphasis on peroxisome proliferation. The paper reviews the biology, physiology, and biochemistry of the peroxisome in rodents and its purported role in mammalian carcinogenesis. The paper then compares what is known about peroxisomes in fish to the mammalian situation, including the capacity of known rodent peroxisome proliferators to cause this phenomenon in fish models.

    Keywords:

    peroxisome, DEHP, rainbow trout


    Author Information:

    Yang, J-H
    Environmental Health and Science, School of Public Health, University of Massachusetts, Amherst, MA

    Kostecki, PT
    Environmental Health and Science, School of Public Health, University of Massachusetts, Amherst, MA

    Calabrese, EJ
    Environmental Health and Science, School of Public Health, University of Massachusetts, Amherst, MA


    Paper ID: STP20115S

    Committee/Subcommittee: E47.09

    DOI: 10.1520/STP20115S


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