SEDL / STP / STP1096-EB / STP20115S

Peroxisome Proliferation as an Epigenetic Mechanism of Carcinogenesis: Relevance to Aquatic Toxicology

Yang, J-H
Environmental Health and Science, School of Public Health, University of Massachusetts, Amherst, MA

Kostecki, PT
Environmental Health and Science, School of Public Health, University of Massachusetts, Amherst, MA

Calabrese, EJ
Environmental Health and Science, School of Public Health, University of Massachusetts, Amherst, MA

Pages: 19    Published: Jan 1990

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Abstract

This paper addresses the issue of epigenetic carcinogenesis in fish models with particular emphasis on peroxisome proliferation. The paper reviews the biology, physiology, and biochemistry of the peroxisome in rodents and its purported role in mammalian carcinogenesis. The paper then compares what is known about peroxisomes in fish to the mammalian situation, including the capacity of known rodent peroxisome proliferators to cause this phenomenon in fish models.