STP1096

    The Aquatic Toxicity of the Sensory Irritant and Riot Control Agent Dibenz(b,f)-1,4-Oxazepine (CR)

    Published: Jan 1990


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    Abstract

    The aquatic toxicity of dibenz(b,f)-1,4-oxazepine (CR) was examined using organisms from three trophic levels. The compound is a peripheral sensory irritant which produces an immediate irritation of the eyes, nose, mouth, skin, and respiratory tract in man. The compound is comprised of a double benzene ring with a shared oxygen molecule and a doublebonded carbon, nitrogen group. The intended use of the compound is for the control of civil disturbances. Acute bioassays were performed using Ankistrodesmus falcatus, Daphnia magna, and Pimephales promelas. A 21-day static renewal test was performed using D. magna.

    A 24-h EC50 of 1.48 mg/L and 48-h EC50 of 0.94 mg/L were calculated for daphnids. Significant differences in reproductive output and body length were observed at 0.50 mg/L using ANOVA in the 21-day chronic assay with D. magna. The 96-h algal growth inhibition test yielded an IC50 in the range of 1.95 to 3.55 mg/L. An LC50 of 2.6 to 2.8 mg/L was determined for the fish. An enhancement compared to controls in reproductive output was observed for both the algae and daphnia at low concentrations of CR. Dose response curves and comparisons of linear and exponential regressions are presented for several of the toxicity tests.

    Keywords:

    dibenz(, b,f, )-1, 4-oxazepine, CR, aquatic toxicology, Ankistrodesmus falcatus, Daphnia magna, Pimephales promelas, chronic toxicity, acute toxicity


    Author Information:

    Johnson, DW
    Research Directorate, Environmental Toxicology BranchU.S. Army Chemical Research, Development and Engineering Center, Aberdeen Proving Ground, MD

    Haley, MV
    Research Directorate, Environmental Toxicology BranchU.S. Army Chemical Research, Development and Engineering Center, Aberdeen Proving Ground, MD

    Landis, WG
    Research Directorate, Environmental Toxicology BranchU.S. Army Chemical Research, Development and Engineering Center, Aberdeen Proving Ground, MD

    Institute of Environmental Toxicology and Chemistry, Huxley College of Environmental Studies, Western Washington University, Bellingham, WA


    Paper ID: STP20106S

    Committee/Subcommittee: E47.10

    DOI: 10.1520/STP20106S


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