Six binary Fe-Cr alloys with chromium levels ranging from 3 to 18% were tensile tested at room temperature following irradiation at 365, 403, and 574°C to doses of 7.4, 37.7, and 34.3 dpa, respectively. Irradiation at 365 and 403°C produced significant strengthening at all chromium levels, with concurrent reductions in ductility. Strength levels were insensitive to composition, irradiation temperature, or neutron exposure. Irradiation at 574°C produced strength increases at only the two highest chromium levels. The results are attributed to dislocation loop and void development at 365 and 403°C, and phase instability at 574°C. No evidence for channel fracture was found.