SEDL / STP / STP900-EB / STP17316S

Bioassay for Testing Protective Glove Performance Against Skin Absorption of Organic Solvents

Boman, A
Research engineer, and professor, National Board of Occupational Safety and Health, Solna,

Wahlberg, JE
Research engineer, and professor, National Board of Occupational Safety and Health, Solna,
Karolinska Hospital, Stockholm,

Pages: 7    Published: Jan 1986

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Abstract

Solvents were administered into closed skin depots on guinea pigs, and the resulting blood concentrations were measured in samples repeatedly withdrawn through a catheter in the carotid artery. The exposure areas were protected with glove membranes of different kinds. Results from experiments with three solvents and various gloves are presented. The authors conclude that this animal model seems suitable for screening purposes and is capable of discerning between various commercial products.