STP1112

    Compressed Tablets as a Potential Pesticide Delivery System

    Published: Jan 1992


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    Abstract

    Solid and liquid pesticides can be formulated into tablets as a delivery system. Inclusion of Lattice microcrystalline cellulose (MCC), a special grade of MCC for agricultural application, and Ac-Di-SolR croscarmellose, a cross-linked sodium carboxy methylcellulose (XL-CMC), into the formulation provides a rapid tablet disintegration time of not more than 5 minutes. Lattice MCC acts as an excellent dry binder when the pesticide is compressed thus imparting desired hardness to the tablets. Simultaneously, the XL-CMC being an excellent disintegrating agent, provides the desirable rapid tablet disintegration time. The tablets disintegrate to prime particles and do not form a hard pack when the suspension is left undisturbed for 1–3 days.

    Keywords:

    excipients, disintegration, compression, tablets, hardness


    Author Information:

    Ibrahim, NI
    Associate Research ChemistManager, Pharmaceutical Technical Services at FMC Corp., Princeton, NJ

    Mehra, DK
    Associate Research ChemistManager, Pharmaceutical Technical Services at FMC Corp., Princeton, NJ


    Paper ID: STP16875S

    Committee/Subcommittee: E35.22

    DOI: 10.1520/STP16875S


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