STP1112: Compressed Tablets as a Potential Pesticide Delivery System

    Ibrahim, NI
    Associate Research ChemistManager, Pharmaceutical Technical Services at FMC Corp., Princeton, NJ

    Mehra, DK
    Associate Research ChemistManager, Pharmaceutical Technical Services at FMC Corp., Princeton, NJ

    Pages: 16    Published: Jan 1992


    Abstract

    Solid and liquid pesticides can be formulated into tablets as a delivery system. Inclusion of Lattice microcrystalline cellulose (MCC), a special grade of MCC for agricultural application, and Ac-Di-SolR croscarmellose, a cross-linked sodium carboxy methylcellulose (XL-CMC), into the formulation provides a rapid tablet disintegration time of not more than 5 minutes. Lattice MCC acts as an excellent dry binder when the pesticide is compressed thus imparting desired hardness to the tablets. Simultaneously, the XL-CMC being an excellent disintegrating agent, provides the desirable rapid tablet disintegration time. The tablets disintegrate to prime particles and do not form a hard pack when the suspension is left undisturbed for 1–3 days.

    Keywords:

    excipients, disintegration, compression, tablets, hardness


    Paper ID: STP16875S

    Committee/Subcommittee: E35.22

    DOI: 10.1520/STP16875S


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