In this study, an analysis of the thermo-mechanical fatigue (TMF) behavior of titanium-based metal matrix composites (MMCs) is accomplished by employing a modified method of cells micromechanics model coupled with a fiber/matrix interfacial failure scheme and the Bodner-Partom unified constitutive theory. Interfacial failure is based on a probabilistic failure criterion which considers the equivalent interfacial compliance to be a function of the interfacial stress. In this approach, the effects of both normal and shear failure of the interface have been included. MMC laminates with angle-ply and quasi-isotropic layups are analyzed for monotonic, cyclic, and thermo-mechanical fatigue loads, and where it is appropriate, comparisons with experimental data are made.