SYMPOSIA PAPER Published: 01 January 1996
STP16089S

Induction of Bone Resorbing Agents by Titanium Particulates: Responses of Macrophages, Fibroblasts and Osteoblasts

Source

Although titanium and titanium alloys demonstrate excellent biocompatability in bulk form, titanium in particulate form can provoke a variety of cellular responses. In this series of experiments, we have shown that commercially pure titanium particulates of phagocytosable size stimulate the secretion of mediators of bone resorption (prostaglandin E2 and interleukin-1) from macrophages and cause bone resorption in organ culture. In addition, we have shown that phagocytosable titanium particles stimulate fibroblasts to up regulate the expression of matrix metalloproteinases (stromelysin and collagenase) without a substantial effect on the tissue inhibitor of these enzymes (TIMP). Titanium particulates also have a suppressive effect on procollagen synthesis by an osteoblast-like cell line. Thus, titanium particulates have the capacity to stimulate bone resorption and inhibit bone matrix formation.

Author Information

Glant, TT
Rush Arthritis and Orthopedics Institute, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
Yao, J
Rush Arthritis and Orthopedics Institute, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
Jacobs, JJ
Rush Arthritis and Orthopedics Institute, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
Price: $25.00
Contact Sales
Related
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Details
Developed by Committee: F04
Pages: 333–345
DOI: 10.1520/STP16089S
ISBN-EB: 978-0-8031-5330-1
ISBN-13: 978-0-8031-2010-5