SEDL / STP / STP1272-EB / STP16089S

Induction of Bone Resorbing Agents by Titanium Particulates: Responses of Macrophages, Fibroblasts and Osteoblasts In Vitro

Glant, TT
Professor, Rush Arthritis and Orthopedics Institute, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL

Yao, J
Research Associate, Rush Arthritis and Orthopedics Institute, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL

Jacobs, JJ
Associate Professor, Rush Arthritis and Orthopedics Institute, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL

Pages: 13    Published: Jan 1996

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Abstract

Although titanium and titanium alloys demonstrate excellent biocompatability in bulk form, titanium in particulate form can provoke a variety of cellular responses. In this series of experiments, we have shown that commercially pure titanium particulates of phagocytosable size stimulate the secretion of mediators of bone resorption (prostaglandin E² and interleukin-1) from macrophages and cause bone resorption in organ culture. In addition, we have shown that phagocytosable titanium particles stimulate fibroblasts to up regulate the expression of matrix metalloproteinases (stromelysin and collagenase) without a substantial effect on the tissue inhibitor of these enzymes (TIMP). Titanium particulates also have a suppressive effect on procollagen synthesis by an osteoblast-like cell line. Thus, titanium particulates have the capacity to stimulate bone resorption and inhibit bone matrix formation.