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Determination of Radionuclides in Biological Fluids Using a High Resolution ICP-MS in Low Resolution Mode

Pickford, CJ
R & D manager, manager - Inorganic Analysis, and senior analyst,AEA Technology/ Analytical Services,Oxfordshire,

Haines, J
R & D manager, manager - Inorganic Analysis, and senior analyst,AEA Technology/ Analytical Services,Oxfordshire,

Heam, R
R & D manager, manager - Inorganic Analysis, and senior analyst,AEA Technology/ Analytical Services,Oxfordshire,

McAughey, J
Manager, Health-Related Aerosols,AEA Technology,Oxfordshire,

Pages: 9    Published: Jan 1998

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Source: STP1344-EB

Abstract

High Resolution (HR) ICP-MS in low resolution mode was used with ultrasonic nebulization to determine long-lived radionuclides and surrogates in human body fluid samples. Although very sensitive, achieving LODs less than 0.1 fg/mL for ²⁴⁴Pu, a number of molecular ion interferences have been encountered from commonly-occurring species which limit sensitivity and require the development of specialized sample preparation routes.

Keywords:
ICP-MS, high resolution, trace analysis, biological samples, radiochemical methods, plutonium, lanthanoids

Paper ID: STP15731S
Committee/Subcommittee: C26.09
DOI: 10.1520/STP15731S
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