SEDL / STP / STP1344-EB / STP15731S

Determination of Radionuclides in Biological Fluids Using a High Resolution ICP-MS in Low Resolution Mode

Pickford, CJ
R & D manager, manager - Inorganic Analysis, and senior analyst, AEA Technology/ Analytical Services, Didcot, Oxfordshire

Haines, J
R & D manager, manager - Inorganic Analysis, and senior analyst, AEA Technology/ Analytical Services, Didcot, Oxfordshire

Heam, R
R & D manager, manager - Inorganic Analysis, and senior analyst, AEA Technology/ Analytical Services, Didcot, Oxfordshire

McAughey, J
Manager, Health-Related Aerosols, AEA Technology, Didcot, Oxfordshire

Pages: 9    Published: Jan 1998

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Abstract

High Resolution (HR) ICP-MS in low resolution mode was used with ultrasonic nebulization to determine long-lived radionuclides and surrogates in human body fluid samples. Although very sensitive, achieving LODs less than 0.1 fg/mL for ²⁴⁴Pu, a number of molecular ion interferences have been encountered from commonly-occurring species which limit sensitivity and require the development of specialized sample preparation routes.