STP1396

    Design and Fabrication of a 3D Scaffold for Tissue Engineering Bone

    Published: Jan 2000


      Format Pages Price  
    PDF Version (464K) 16 $25   ADD TO CART
    Complete Source PDF (4.2M) 16 $83   ADD TO CART


    Abstract

    Autogenous cell transplantation is one of the most promising new techniques being developed for bone generation as it eliminates problems of donor site scarcity, immune rejection and pathogen transfer. Osteoblasts obtained from an individual patient can be grown in culture and seeded onto a three-dimensional scaffold that will slowly degrade and resorb as the bone or cartilage structures grow and assimilate in vivo. The three-dimensional (3D) scaffold provides the necessary support for cells to maintain their differentiated state and defines the overall shape of the new bone and cartilage. The necessity of using a scaffold structure as the basic template of engineering tissues has encouraged the study the application of advanced manufacturing technologies in this field. For example, rapid prototyping (RP) technologies such as fused deposition modeling (FDM) can be used to fabricate complex 3D structures based on two- dimensional (2D) cross-sectional data obtained by slicing a computer-aided design (CAD) models. FDM is currently being applied in our laboratory to fabricate bioresorbable 3D scaffolds of various porosities and micro-architecture for tissue engineering bone.

    Keywords:

    Tissue engineering, bioresorbable 3D scaffolds, fused deposition modeling


    Author Information:

    Hutmacher, DW
    Laboratory for Biomedical Engineering, National University of Singapore,

    National University of Singapore,

    Teoh, SH
    Laboratory for Biomedical Engineering, National University of Singapore,

    Zein, I
    Laboratory for Biomedical Engineering, National University of Singapore,

    Ng, KW
    Laboratory for Biomedical Engineering, National University of Singapore,

    Schantz, J-T
    Laboratory for Biomedical Engineering, National University of Singapore,

    Leahy, JC
    National University of Singapore,


    Paper ID: STP15307S

    Committee/Subcommittee: F04.04

    DOI: 10.1520/STP15307S


    CrossRef ASTM International is a member of CrossRef.