SYMPOSIA PAPER Published: 01 January 2000
STP15307S

Design and Fabrication of a 3D Scaffold for Tissue Engineering Bone

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Autogenous cell transplantation is one of the most promising new techniques being developed for bone generation as it eliminates problems of donor site scarcity, immune rejection and pathogen transfer. Osteoblasts obtained from an individual patient can be grown in culture and seeded onto a three-dimensional scaffold that will slowly degrade and resorb as the bone or cartilage structures grow and assimilate in vivo. The three-dimensional (3D) scaffold provides the necessary support for cells to maintain their differentiated state and defines the overall shape of the new bone and cartilage. The necessity of using a scaffold structure as the basic template of engineering tissues has encouraged the study the application of advanced manufacturing technologies in this field. For example, rapid prototyping (RP) technologies such as fused deposition modeling (FDM) can be used to fabricate complex 3D structures based on two- dimensional (2D) cross-sectional data obtained by slicing a computer-aided design (CAD) models. FDM is currently being applied in our laboratory to fabricate bioresorbable 3D scaffolds of various porosities and micro-architecture for tissue engineering bone.

Author Information

Hutmacher, DW
Laboratory for Biomedical Engineering, National University of Singapore, Singapore National University of Singapore, Singapore
Teoh, SH
Laboratory for Biomedical Engineering, National University of Singapore, Singapore
Zein, I
Laboratory for Biomedical Engineering, National University of Singapore, Singapore
Ng, KW
Laboratory for Biomedical Engineering, National University of Singapore, Singapore
Schantz, J-T
Laboratory for Biomedical Engineering, National University of Singapore, Singapore
Leahy, JC
National University of Singapore, Singapore
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Details
Developed by Committee: F04
Pages: 152–167
DOI: 10.1520/STP15307S
ISBN-EB: 978-0-8031-5444-5
ISBN-13: 978-0-8031-2870-5