SEDL / STP / STP1396-EB / STP15304S

Modulation of Pore Topography of Tissue Engineering Constructs

Burg, KJL
Assistant professor, Clemson University, 501 Rhodes Engineering Research Center, Clemson, SC

Austin, CE
Laboratory technician II and senior research analyst, Carolinas Medical Center, Charlotte, NC

Swiggett, JP
Laboratory technician II and senior research analyst, Carolinas Medical Center, Charlotte, NC

Pages: 9    Published: Jan 2000

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Abstract

Absorbable materials can be used in tissue engineering to provide a porous template into which cells can be dispersed. The template not only serves as the delivery vehicle for implantation, but it also provides the form that the developing tissue will eventually take. The physicochemical properties of the material influence the development of cells within the template. This preliminary study assessed the effect of two template processing techniques on cellular attachment using sheep uterus smooth muscle cells and poly-1-lactide constructs. The results demonstrate that porogen selection in solvent cast, particulate-leached templates can radically change cellular attachment behavior.