Specific physics-dosimetry-metallurgy issues are considered that will impact on current and future revisions of the thirty-four standards that have been identified for the next revision of the ASTM E706 Master Matrix of LWR Surveillance Standards, E706(0). Two major classes of technical issues are identified, namely those associated with 1) physics dosimetry methodology and 2) physically based modelling methodology. Symposium papers were reviewed to select the more important issues that exist in these two classes. A synthesis of these issues is presented.