STP1144

    Biocompatibility of Polymethyl Methacrylate With and Without Barium Sulfate in the Rat Subcutaneous Air Pouch Model

    Published: Jan 1992


      Format Pages Price  
    PDF Version (160K) 9 $25   ADD TO CART
    Complete Source PDF (6.5M) 9 $65   ADD TO CART


    Abstract

    A pseudosynovial lining is a characteristic finding at the bone/cement interface of a loose prosthesis. Repeated injection of air into the subcutaneous tissue of a rat results in the formation of a cavity with a lining that shares many histologic and secretory properties with this pseudosynovium. The authors used this model to investigate the differences in biological response to polymethyl methacrylate with and without barium sulfate, and found that the presence of barium sulfate led to a markedly increased inflammatory reaction.

    Keywords:

    particulates, implants, biocompatibility, polymethyl methacrylate, pseudosynovium, barium sulfate, particulate debris


    Author Information:

    Lazarus, MD
    Hospital of the University of Pennsylvania, Philadelphia, PA

    Cuckler, JM
    University of Pennsylvania School of Medicine, Philadelphia, PA

    Mitchell, J
    University of Pennsylvania School of Medicine, Philadelphia, PA

    Schumacher, HR
    University of Pennsylvania School of Medicine, Philadelphia, PA

    Baker, DG
    University of Pennsylvania School of Medicine, Philadelphia, PA

    Ducheyne, P
    University of Pennsylvania, Philadelphia, PA

    Imonitie, V
    University of Pennsylvania School of Medicine, Philadelphia, PA


    Paper ID: STP14859S

    Committee/Subcommittee: F04.16

    DOI: 10.1520/STP14859S


    CrossRef ASTM International is a member of CrossRef.