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Biocompatibility of Polymethyl Methacrylate With and Without Barium Sulfate in the Rat Subcutaneous Air Pouch Model

Lazarus, MD
Hospital of the University of Pennsylvania,PA,

Cuckler, JM
University of Pennsylvania School of Medicine,PA,

Mitchell, J
University of Pennsylvania School of Medicine,PA,

Schumacher, HR
University of Pennsylvania School of Medicine,PA,

Baker, DG
University of Pennsylvania School of Medicine,PA,

Ducheyne, P
University of Pennsylvania,PA,

Imonitie, V
University of Pennsylvania School of Medicine,PA,

Pages: 9    Published: Jan 1992

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Source: STP1144-EB

Abstract

A pseudosynovial lining is a characteristic finding at the bone/cement interface of a loose prosthesis. Repeated injection of air into the subcutaneous tissue of a rat results in the formation of a cavity with a lining that shares many histologic and secretory properties with this pseudosynovium. The authors used this model to investigate the differences in biological response to polymethyl methacrylate with and without barium sulfate, and found that the presence of barium sulfate led to a markedly increased inflammatory reaction.

Keywords:
particulates, implants, biocompatibility, polymethyl methacrylate, pseudosynovium, barium sulfate, particulate debris

Paper ID: STP14859S
Committee/Subcommittee: F04.16
DOI: 10.1520/STP14859S
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