STP1144

    Histomorphological Reaction Patterns of the Bone to Diverse Particulate Implant Materials in Man and Experimental Animals

    Published: Jan 1992


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    Abstract

    Implantation of an orthopedic device into or onto bone induces the formation of an interface membrane separating the one from the other. The histological reaction patterns described herein are those occurring in the interface membranes of a cemented arthroplasty, cementless isoelastic arthroplasty, cementless carbon-fiber/polysulfone arthroplasty, intraosseous anchorage site of a carbon-fiber composite ligament, partially biodegradable composite polylactic acid polymer/carbon plate, and stainless steel nail. The tissue response to the introduction of Taurolin into bone is also reported. Under all these circumstances, the morphological findings are rather monotonous, inasmuch as inflammatory, granulomatous, and cicatrizing changes are induced by the implanted foreign materials. The authors suggest that it is not the uniqueness of any one implant component which is responsible for the development of the interface membrane but rather that one or more diverse, nonspecific, biologically indigestible wear particles, released at the bone/implant interface, trigger the self-perpetuating growth of the interface membrane.

    Keywords:

    particulates, implants, arthroplasty, internal fixation plate, interface membrane, composite materials, polymeric particulate material, metallic particulate materials, carbon-fiber composite ligaments, stainless steel nails, Taurolin


    Author Information:

    Boss, JH
    Director and chief physicianchief physician and director, Bnai Zion—Medical Center, Center for Implant Surgery, the Rappaport Family Institute for Research in the Medical Sciences, and the Faculty of Medicine of the Technion, Israel Institute of Technology, Haifa,

    Shajrawi, I
    Director and chief physicianchief physician and director, Bnai Zion—Medical Center, Center for Implant Surgery, the Rappaport Family Institute for Research in the Medical Sciences, and the Faculty of Medicine of the Technion, Israel Institute of Technology, Haifa,

    Soudry, M
    Director and chief physicianchief physician and director, Bnai Zion—Medical Center, Center for Implant Surgery, the Rappaport Family Institute for Research in the Medical Sciences, and the Faculty of Medicine of the Technion, Israel Institute of Technology, Haifa,

    Mendes, DG
    Director and chief physicianchief physician and director, Bnai Zion—Medical Center, Center for Implant Surgery, the Rappaport Family Institute for Research in the Medical Sciences, and the Faculty of Medicine of the Technion, Israel Institute of Technology, Haifa,


    Paper ID: STP14856S

    Committee/Subcommittee: F04.22

    DOI: 10.1520/STP14856S


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