STP1365: Serum Protein Carriers of Chromium in Patients with Cobalt-Base Alloy Total Joint Replacement Components

    Hallab, NJ
    Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

    Jacobs, JJ
    Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

    Skipor, A
    Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

    Black, J
    Principal, IMN Biomaterials, King of Prussia, PA

    Mikecz, K
    Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

    Galante, JO
    Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

    Pages: 10    Published: Jan 1999


    Abstract

    The distribution of chromium (Cr) in fractionated serum was studied from peripheral blood of patients with and without Cr-containing Cobalt-base alloy total joint replacements: 1)10 patients with cobalt-chromium-base alloy prostheses; and 2) 10 age-matched controls without implants. Two molecular weight ranges were found to primarily bind Cr (at ≈70 kD and ≈140–180 kD) in patients with Cobalt-base alloy total joint replacements. This pattern of concentration-dependent metal-protein binding within molecular weight ranges that include immunoglobulins warrants further investigation.

    Keywords:

    metal ion release, biocompatibility, protein, chromium, corrosion


    Paper ID: STP14275S

    Committee/Subcommittee: F04.16

    DOI: 10.1520/STP14275S


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