SEDL / STP / STP1365-EB / STP14275S

Serum Protein Carriers of Chromium in Patients with Cobalt-Base Alloy Total Joint Replacement Components

Hallab, NJ
Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

Jacobs, JJ
Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

Skipor, A
Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

Black, J
Principal, IMN Biomaterials, King of Prussia, PA

Mikecz, K
Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

Galante, JO
Assistant Professor, Professor and Director, Section of Biomaterials, Research Associate, Associate Professor, Professor and Director Rush Arthritis and Orthopedics Institute, Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL

Pages: 10    Published: Jan 1999

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Abstract

The distribution of chromium (Cr) in fractionated serum was studied from peripheral blood of patients with and without Cr-containing Cobalt-base alloy total joint replacements: 1)10 patients with cobalt-chromium-base alloy prostheses; and 2) 10 age-matched controls without implants. Two molecular weight ranges were found to primarily bind Cr (at ≈70 kD and ≈140–180 kD) in patients with Cobalt-base alloy total joint replacements. This pattern of concentration-dependent metal-protein binding within molecular weight ranges that include immunoglobulins warrants further investigation.