Proper evaluation, simulation, and subsequent testing of the forces acting on a stone cladding anchorage system are critical elements in the overall success of the anchorage system design as it relates to serviceability, safety, durability, and aesthetics. In some cases, to accurately predict anchorage performance, the stone cladding system must be tested as a whole under service loading conditions to observe the total deflection of the entire anchorage system assembly, including anchors, studs, flashing, drywall, toggles, mounting screws, etc. Presented is a case study which incorporated in-place testing to simulate the combined dead load and wind load forces acting on a penthouse level mechanical screen wall on a multi-story building in the Denver-Metro area. Testing on a series of stone cladding anchorage systems was performed to help determine if design deflection criteria could be achieved.