STP1452

    Storage and Transport Issues for Tissue Engineered Medical Products

    Published: Jan 2004


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    Abstract

    A prominent barrier to widespread commercialization of tissue engineered medical products (TEMPs) is the development of storage and transport technologies to maintain high product viability and integrity at point of use. Advances in biostabilization and low temperature biology have produced effective preservation technologies for cells and tissues in areas of hypothermic storage, cryopreservation by freezing and vitrification, and anhydrobiotic preservation. Preservation methods are anticipated to progress in step with development of TEMPs and may ultimately influence construct designs, as the final form of these products are determined. However, development of preservation methods is complex and requires optimization of several chemical and biophysical processes to achieve maximal viability and stability. The development of standards for materials and processes used in preserving TEMPs will be integral in ensuring final product quality and integrity pertaining to pre-process treatment, materials and containment systems, preservation processes, storage, transport, restoration and post-process treatment.

    Keywords:

    tissue engineering, biopreservation, cryopreservation, vitrification, hypothermic storage, anhydrobiosis, freeze-drying, storage and transport technology, stabilization


    Author Information:

    Walsh, JR
    Laboratory Director, Vice President of Research and Development, and Senior Vice President of Scientific, Clincal and Regulatory Affairs, Organ Recovery Systems, Inc., Charleston, SC

    Taylor, MJ
    Laboratory Director, Vice President of Research and Development, and Senior Vice President of Scientific, Clincal and Regulatory Affairs, Organ Recovery Systems, Inc., Charleston, SC

    Brockbank, KGM
    Laboratory Director, Vice President of Research and Development, and Senior Vice President of Scientific, Clincal and Regulatory Affairs, Organ Recovery Systems, Inc., Charleston, SC


    Paper ID: STP11647S

    Committee/Subcommittee: F04.43

    DOI: 10.1520/STP11647S


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