STP1438: Corrosion Products Generated from Mechanically Assisted Crevice Corrosion of Stainless Steel Orthopaedic Implants

    Urban, RM
    DirectorProfessorDirectorDirectorAssistant ProfessorDirectorAssociate ProfessorProfessorDirectorProfessor, Implant Pathology LaboratorySection of Biomaterials ResearchMetal Ion LaboratoryBiomaterials Testing LaboratorySection of Biochemistry and Molecular BiologyRush-Presbyterian-St. Luke's Medical Center, Chicago, IL

    Jacobs, JJ
    DirectorProfessorDirectorDirectorAssistant ProfessorDirectorAssociate ProfessorProfessorDirectorProfessor, Implant Pathology LaboratorySection of Biomaterials ResearchMetal Ion LaboratoryBiomaterials Testing LaboratorySection of Biochemistry and Molecular BiologyRush-Presbyterian-St. Luke's Medical Center, Chicago, IL

    Gilbert, JL
    Professor and Chairman, Syracuse University, Syracuse, NY

    Skipor, AK
    DirectorProfessorDirectorDirectorAssistant ProfessorDirectorAssociate ProfessorProfessorDirectorProfessor, Implant Pathology LaboratorySection of Biomaterials ResearchMetal Ion LaboratoryBiomaterials Testing LaboratorySection of Biochemistry and Molecular BiologyRush-Presbyterian-St. Luke's Medical Center, Chicago, IL

    Hallab, NJ
    DirectorProfessorDirectorDirectorAssistant ProfessorDirectorAssociate ProfessorProfessorDirectorProfessor, Implant Pathology LaboratorySection of Biomaterials ResearchMetal Ion LaboratoryBiomaterials Testing LaboratorySection of Biochemistry and Molecular BiologyRush-Presbyterian-St. Luke's Medical Center, Chicago, IL

    Mikecz, K
    DirectorProfessorDirectorDirectorAssistant ProfessorDirectorAssociate ProfessorProfessorDirectorProfessor, Implant Pathology LaboratorySection of Biomaterials ResearchMetal Ion LaboratoryBiomaterials Testing LaboratorySection of Biochemistry and Molecular BiologyRush-Presbyterian-St. Luke's Medical Center, Chicago, IL

    Glant, TT
    DirectorProfessorDirectorDirectorAssistant ProfessorDirectorAssociate ProfessorProfessorDirectorProfessor, Implant Pathology LaboratorySection of Biomaterials ResearchMetal Ion LaboratoryBiomaterials Testing LaboratorySection of Biochemistry and Molecular BiologyRush-Presbyterian-St. Luke's Medical Center, Chicago, IL

    Marsh, JL
    Professor, the University of Iowa College of Medicine, Iowa City, IA

    Galante, JO
    DirectorProfessorDirectorDirectorAssistant ProfessorDirectorAssociate ProfessorProfessorDirectorProfessor, Implant Pathology LaboratorySection of Biomaterials ResearchMetal Ion LaboratoryBiomaterials Testing LaboratorySection of Biochemistry and Molecular BiologyRush-Presbyterian-St. Luke's Medical Center, Chicago, IL

    Pages: 11    Published: Jan 2003


    Abstract

    Accelerated corrosion of metallic implants in vivo can generate both soluble and insoluble products that can be detected locally and systemically. Retrieved stainless steel implants for trauma fixation or spinal instrumentation demonstrate iron and chromium-containing solid products of corrosion deposited around corroded modular junctions and as phagocytosable particles in the adjacent tissues. In some cases, the resulting adverse local tissue reaction has been associated with pain, inflammation and osteolysis, requiring removal of the implant. In vitro cell and organ culture studies confirm that corrosion products such as particles of chromium phosphate can elicit proinflammatory cytokine secretion from macrophages and promote macrophage-mediated bone resorption. Systemically, soluble corrosion products of chromium can be detected in the serum of selected patients with accelerated corrosion of chromium-containing implants. Metal-protein binding studies indicate that the high molecular weight serum proteins including immunoglobulins have the highest affinity for chromium. These findings stress the importance of the design of modular junctions to minimize corrosion of stainless steels used in orthopaedic appliances.

    Keywords:

    Stainless steel, corrosion, crevice, fretting, modularity, chromium, particulate debris, metal ions, osteolysis, cytokines, serum proteins, systemic dissemination


    Paper ID: STP11169S

    Committee/Subcommittee: F04.93

    DOI: 10.1520/STP11169S


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