Published: Jan 2003
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MORE THAN 500,000 SURGICAL PROCEDURES using bone grafts or bone graft substitutes are performed annually in the United States. Fractures and traumatic bone defects constitute a large proportion of these procedures, second only to spinal arthrodeses. This expanding market for grafts has stimulated the development over the last 20 years of a host of different bone graft substitutes composed of calcium phosphate or calcium sulfate biomaterials. No fewer than 30 bone graft substitutes and allograft products are currently in various stages of clinical development. The purpose of this chapter is to discuss the critical clinical issues in the development of bone graft substitutes in orthopedic trauma care.
University of Texas Southwestern Medical School, Dallas, TX
Paper ID: MONO10074M