THE USE OF CALCIUM SULFATE as a bone graft implant has been reported in the clinical literature for more than a century. The history of calcium sulfate usage for both dental and orthopedic applications can be found in reviews by many authors including Bahn, Damien, Hulbert, Mackey, Peltier, and Smith [2,5,10,14,19,23]. A review of the recent development of multiple calcium sulfate bone graft products, their clinical performance, regulatory status, and standard activity will be surveyed and presented.