MONO6

    Chapter 5-The Development of Bone Graft Materials Using Various Formulations of Demineralized Bone Matrix

    Published: Jan 2003

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    Abstract

    THE DISCOVERY OF THE PROTEINS CAPABLE of inducing bone formation can be traced back to the work by Marshall Urist in the mid-1960s [1]. When Urist discovered that the implantation of various preparations of demineralized bovine bone into rat muscle resulted in the deposition of ectopic bone, he began to investigate the cause of this response. This led to the eventual isolation and characterization of bone morphogenetic proteins (BMPs). Although Urist's early studies are often referred to as the “discovery of BMPs,” they also introduced the scientific community to the osteoconductive capabilities of demineralized bone matrix. Following Urist's initial work, a significant amount of research has shown the ability of demineralized matrix (DBM) to induce bone formation [2-8]. The success of DBM in the laboratory eventually translated into its use as a clinical bone graft material. Particulate DBM saw its first use in patients as a bone void filler in dental and periodontal surgeries [9]. The range of applications soon expanded to include the current areas of orthopedics [10-13] and oral and maxillofacial surgery [14-17].


    Author Information:

    Tomford, WW

    Borden, M
    Interpore Cross International, Irvine, CA


    Paper ID: MONO10061M

    Committee/Subcommittee: F04.48

    DOI: 10.1520/MONO10061M


    CrossRef ASTM International is a member of CrossRef.

    ISBN10: 0-8031-3356-1
    ISBN13: 978-0-8031-3356-3