ALLOGRAFT BONE AND BONE GRAFT substitutes based on human allograft are widely used in orthopedic surgery. Some of the more common indications for the use of human bone allograft and its derivatives include the use of large structural allografts in tumor reconstructions, morcellized cancellous grafts for a variety of joint arthroplasty and trauma applications, as well as demineralized bone matrix (DBM) products to augment arthrodesis procedures in the hand, foot, spine, and elsewhere.