Volume 2, Issue 1 (January 2005)

    The Role of TGA-DTA in the Initial Evaluation of the Solid State Forms for Pharmaceutical New Chemical Entities, Part 1: Evaluation of Pure Forms

    (Received 24 May 2004; accepted 15 September 2004)

    Published Online: 2005

    CODEN: JAIOAD

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    Abstract

    TGA-DTA plays a central role in the strategy outlined for early evaluation of the solid state forms available to pharmaceutical new chemical entities. At this early stage of development, compound and time are typically at a premium, so a successful strategy requires making the best possible use of the materials and time available. In addition, because of time and compound limitations, the goal of a solid state investigation is focused upon early stage objectives rather than development of a complete understanding of all available solid state forms. The TGA-DTA is well suited to addressing these needs.


    Author Information:

    Redman-Furey, NL
    Principal Scientist, P&G Pharmaceuticals, Inc., Norwich, New York,

    Dicks, ML
    Principal Researcher, P&G Pharmaceuticals, Inc., Norwich, New York,

    Godlweski, J
    Principal Scientist, P&G Pharmaceuticals, Inc., Norwich, New York,

    Vaughn, DC
    Senior Researcher, P&G Pharmaceuticals, Inc., Norwich, New York,

    Collins, WJ
    Senior Researcher, P&G Pharmaceuticals, Inc., Norwich, New York,


    Stock #: JAI12791

    ISSN: 1546-962X

    DOI: 10.1520/JAI12791

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    Author
    Title The Role of TGA-DTA in the Initial Evaluation of the Solid State Forms for Pharmaceutical New Chemical Entities, Part 1: Evaluation of Pure Forms
    Symposium Techniques in Thermal Analysis:Hyphenated Techniques, Thermal Analysis of the Surface, and Fast Rate, 2004-05-25
    Committee E37