Use of a TG/DTA/Raman System to Monitor Dehydration and Phase Conversions

    Volume 2, Issue 7 (July 2005)

    ISSN: 1546-962X

    CODEN: JAIOAD

    Published Online: 8 June 2005

    Page Count: 10


    Kern, ASB
    Senior Research, Procter & Gamble Pharmaceuticals, Norwich, NY

    Collins, WJ
    Senior Research, Procter & Gamble Pharmaceuticals, Norwich, NY

    Cambron, RT
    Principal Scientist, Procter & Gamble Pharmaceuticals, Norwich, NY

    Redman-Furey, NL
    Senior Scientist, Procter & Gamble Pharmaceuticals, Norwich, NY

    (Received 24 May 2004; accepted 8 December 2004)

    Abstract

    Use of a TG/DTA/Raman system enabled real time collection of Raman spectra during the dehydration of Risedronate, the active pharmaceutical ingredient in the osteoporosis drug Actonel. Raman spectra collected during the dehydration of this material show a crystal lattice adjustment below the boiling point of water facilitating interpretation of the TG/DTA thermal profile. Raman spectra also revealed recrystallization processes subsequent to loss of lattice water that were not evident in the thermal analysis profile. Spectral evidence showing the formation and disappearance of a second hydrate form are observed during the dehydration of this material. In addition, spectral evidence indicating the presence of an anhydrate form of this material are observed prior to thermal induced degradation of this material.


    Paper ID: JAI12790

    DOI: 10.1520/JAI12790

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    Author
    Title Use of a TG/DTA/Raman System to Monitor Dehydration and Phase Conversions
    Symposium Techniques in Thermal Analysis:Hyphenated Techniques, Thermal Analysis of the Surface, and Fast Rate, 2004-05-25
    Committee E37