Volume 4, Issue 3 (March 2007)

    High-Altitude Testing and Evaluation of Liquid Pharmaceutical Glass and Plastic Bottles to Detect Leaks

    (Received 31 July 2006; accepted 7 February 2007)

    Published Online: 2007

    CODEN: JAIOAD

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    Abstract

    This paper discusses the impact on package integrity of high-altitude shipments of glass and plastic bottles. High altitudes are encountered when trucks travel over mountain passes and when cargo and feeder aircraft transport packages in nonpressurized or partially pressurized cargo holds. This is the second research study conducted on liquid product shipments. The first was done on liquid hazardous material combination packaging. The testing of pharmaceutical packaging is critical since the integrity of the product may be compromised during shipping and handling. Current shipping tests performed in labs do not account for simultaneous pressure changes and vibration. This study shows that packages currently being used for shipments of liquid pharmaceuticals that are tested to existing ASTM and ISO shipping tests are often inadequate, and can result in a significant number of leakers. Testing under combined vibration and pressure is necessary to ensure integrity.


    Author Information:

    Singh, S. P.
    Professor, Michigan State University, East Lansing, MI

    Burgess, G.
    Professor, Michigan State University, East Lansing, MI

    Singh, J.
    Assistant Professor, Cal Poly State University, San Luis Obispo, CA

    Lockhart, H.
    Professor, Michigan State University, East Lansing, MI


    Stock #: JAI100742

    ISSN: 1546-962X

    DOI: 10.1520/JAI100742

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    Author
    Title High-Altitude Testing and Evaluation of Liquid Pharmaceutical Glass and Plastic Bottles to Detect Leaks
    Symposium , 0000-00-00
    Committee D10