(Received 7 March 2006; accepted 15 February 2007)
Published Online: 2007
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In order to establish a structure and property (melting and oxidative or thermal degradation, or both) relationship for a United States Pharmacopeias (USP) set of standard drugs, they were evaluated by fast scan differential scanning calorimetry. A critical problem in characterizing the endothermic melting of a drug is to determine the melting range and if a chemical melts and immediately degrades. The stability of standard drugs is based on a comparison of their thermal properties at widely varying ramp or heating rates from 10 to 100°C/min. A stable crystalline drug has an obvious melting endotherm followed by a stable baseline. An unstable crystalline drug melts and immediately degrades as viewed by a shifting melt endo
Riga, Alan T.
Cleveland State University, Cleveland, OH
TA Instruments, New Castle, DE
Alexander, Kenneth S.
College of Pharmacy, University of Toledo, Toledo, OH
Stock #: JAI100528