ISSN: 1546-962X
Published Online: 1 June 2005
Page Count: 8

Acoustic ‘Distributed Source’ Mixing of Smallest Fluid Volumes
Rathgeber, A
Engineer, Advalytix AG,

Wassermeier, M
Systems Development, Advalytix AG,

Wixforth, A
CTO, Advalytix AG, and Chair for Exptl. Physics, University of Augsburg,

(Received 31 March 2004; accepted 22 March 2005)

Abstract

Acoustically driven mixing of small fluid volumes is reported. Using surface acoustic waves on a mixer chip and employing wave guiding effects in a substrate enables us to distribute a set of “virtual sources” for acoustic streaming over large areas. We demonstrate the applicability of our mixing technique to microarray applications, for mixing of individual wells in a micro titer plate, and other state-of-the-art hybridization assays.

Keywords:
microfluidics, acoustic agitation, mixing, surface acoustic waves, biochips

Paper ID: JAI12829
DOI: 10.1520/JAI12829
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